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Graphical presentation of CX-5461-mediated activation in the cytosolic DNA sensing pathway. cGAS binding towards the cytosolic DNA activates the secondary messenger two,three-cGAMP working with cGAS as a catalyst. Activated STING buds off the ER moving to the perinuclear Golgi, in which it truly is palmitoylated.The inexperienced ones contained a l

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